Absence of FGFR3–TACC3 rearrangement in hematological malignancies with numerical chromosomal alteration

FGFR–TACC, found in different tumor types, is characterized by the fusion of a member fibroblast grown factor receptor (FGFR) tyrosine kinase (TK) family to transforming acidic coiled-coil (TACC) proteins. Because chromosome numerical alterations, hallmarks FGFR–TACC fusions are present many hematological disorders and there no data on prevalence, we studied series patients with acute myeloid leukemia myelodysplastic syndrome who presented alterations using cytogenetic traditional analysis. None analyzed samples showed FGFR3–TACC3 gene fusion, so screening for this mutation at diagnosis not recommended.